Reconocimiento y tratamiento precoz de las FLUCTUACIONES en la ENFERMEDAD DE PARKINSON


  • Introducción
  • Clinical Presentation and Magnitude of the Problem
  • Prevalence
  • Mechanisms of Motor Complications
  • Severe LIDs
  • Motor Complications in Parkinson’s disease
  • Key Factors in the origin of treatment-related complications
  • Summary of changes in response to levodopa throughout evolution
  • Putamen raclopride binding (Response to levodopa ) correlate with L-Dopa plasma level
  • Levodopa-induced Dyskinesias
  • Levodopa-induced dyskinesias and somatotopic representation
  • “Silly walks in PD”
  • The basal ganglia and levodopa in PD
  • Levodopa-induced dyskinesias
  • Large levodopa doses lead to marked changes in striatal dopaminergic activity
  • Mechanisms of Fluctuations & Dyskinesias Summary
  • Pathogenesis of Levodopa-Related Motor Complications
  • Turno de preguntas