Introducción
Clinical Presentation and Magnitude of the Problem
Prevalence
Mechanisms of Motor Complications
Severe LIDs
Motor Complications in Parkinson’s disease
Key Factors in the origin of treatment-related complications
Summary of changes in response to levodopa throughout evolution
Putamen raclopride binding (Response to levodopa ) correlate with L-Dopa plasma level
Levodopa-induced Dyskinesias
Levodopa-induced dyskinesias and somatotopic representation
“Silly walks in PD”
The basal ganglia and levodopa in PD
Levodopa-induced dyskinesias
Large levodopa doses lead to marked changes in striatal dopaminergic activity
Mechanisms of Fluctuations & Dyskinesias Summary
Pathogenesis of Levodopa-Related Motor Complications
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